In this work we developed

2018-10-20

In this work, we developed multiple tools to interrogate this autocrine and paracrine signaling loop involving α-5 laminin production by hPSCs. The use of the inducible short hairpin lines allowed us to control the dynamics of α-5 laminin production in a reversible manner. However, the interpretatio

Taken together our findings suggest that

2018-10-20

Taken together, our findings suggest that in PD, the heterozygous GBA-N370S mutation leads to the misprocessing of GCase, ER stress upregulation, and autophagic/lysosomal dysfunction in dopaminergic neurons. We propose that this combination of disturbances impairs protein homeostasis in dopamine neu

Some of the cultured cardiac

2018-10-20

Some of the cultured cardiac MSCs also stained positive for the mesodermal progenitor marker TBX18 (Mommersteeg et al., 2010; Christoffels et al., 2006); future studies need to be performed in order to address whether some of the PDGFR-α+ and TBX18+ mth1 inhibitor potentially share a developmental

Hello world!

2018-07-29