• br Patients and Methods br

  2018-11-09

  

  Patients and Methods Results Discussion In this study of children with invasive bacterial disease, we found an association between a polymorphism in the NFKBIE gene and increased susceptibility to IPD. This association was specific for the risk of pneumococcal meningitis. A number of other

• Beyond a desire to understand

  2018-11-08

  

  Beyond a desire to understand the physiologic and pathologic mechanisms of erythropoiesis regulation, there is a need for methods for producing artificial RBCs from stem cells. The removal of feeder stromal cells and serum/plasma is critical for any method to be feasible for clinical applications an

• Epigenetic mechanisms are essential for normal brain

  2018-11-08

  

  Epigenetic mechanisms are essential for normal SCH727965 Supplier development and function and dysregulation in chromatin regulation results in neurodegenerative disorders, such as Alzheimer disease (Graff and Mansuy, 2009). It has been shown that expression of cell cycle-related proteins increases

• br Results br Discussion Our findings illustrate a transcrip

  2018-11-08

  

  Results Discussion Our findings illustrate a transcriptional circuit involving Cdx4 and Sall4 that is required for the developmental transition from mesoderm to blood formation in zebrafish. By integrating ChIP-seq and expression profiling data from zebrafish embryos, we show that Sall4 shares

• br Results br Discussion Here we

  2018-11-08

  

  Results Discussion Here, we provide evidence showing the expression of PRDM1 in human fetal germline tissues. Although it has been reported that Prdm1 is absent in zebrafish PGCs (Ng et al., 2006), the expression of PRDM1 in the germ cell lineage appears to be evolutionarily conserved between

• Besides their direct effect on cartilage ASCs might act on

  2018-11-08

  

  Besides their direct effect on cartilage, ASCs might act on the other joint tissues as synovial membrane, ligaments, meniscus and subchondral bone that are also altered in OA. Although OA is not considered an inflammatory disease, pro-inflammatory cytokines, namely IL-1β and TNF-α, are secreted by O

• br Patients and methods br Introduction Embryonic stem

  2018-11-08

  

  Patients and methods Introduction Embryonic stem (ES) SQ 22536 can give rise, in vivo, to the ectodermal, endodermal, and mesodermal germ layers and, in vitro, can differentiate into multiple cell lineages (Reubinoff et al., 2000; Wobus and Boheler, 2005). This ability to form different cell

• HSCs isolated by the set of markers which

  2018-11-08

  

  HSCs isolated by the set of markers which are Lin−/Sca-1+/C-kit+ (LSK) have been also reported to be heterogeneous (Osawa et al., 1996). Moreover, Sca-1 expression differs between mouse strains and therefore is not very effective to enrich HSCs (Spangrude and Brooks, 1993). Likewise, the SLAM family

• Many previous studies examining mutagenesis in pluripotent c

  2018-11-08

  

  Many previous studies examining mutagenesis in pluripotent cells have utilized UV radiation to induce DNA damage (Bártová et al., 2011; Martins-Taylor and Xu, 2012; Momcilović et al., 2009; Bañuelos et al., 2008; de Waard et al., 2008; Maynard et al., 2008). Damage of this sort is normally repaired

• Further support for the hierarchical

  2018-11-08

  

  Further support for the hierarchical two-stem-cell model came with the discovery of an additional reserve ISC marker locus, Hopx, encoding an atypical homeodomain protein with functions in early heart development (Chen et al., 2002). An IRES-CreERT2 cassette inserted into the endogenous Hopx locus r

• Compared to treatments with other FGF isoforms stimulation w

  2018-11-08

  

  Compared to treatments with other FGF2 isoforms, stimulation with 22.5kDa FGF2 results in lower stem cell gene expression in hESCs (Fig. 4d), weaker proliferative activity in human dermal fibroblasts (Fig. 5), and lower relative mitogenic activity in BaF3 order AEBSF ectopically expressing FGFR1 II

• Previously in vitro studies of CIPN were performed in

  2018-11-08

  

  Previously, in vitro studies of CIPN were performed in rat pheochromocytoma or SK-N-SH human neuroblastoma cell lines as model systems to evaluate decreases in neurite outgrowth in response to neurotoxic chemotherapy drugs, such as paclitaxel, vincristine, oxaliplatin and cisplatin (Rovini et al., 2

• Introduction Human pluripotent stem cells hPSCs i e human em

  2018-11-08

  

  Introduction Human pluripotent stem γ-Secretase inhibitor IX (hPSCs), i.e., human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), can give rise to functional neurons (reviewed in Gage and Temple, 2013). Human peripheral neurons are difficult to differentiate, but a

• Many laboratories have analyzed and reported the Pb isotopic

  2018-11-07

  

  Many laboratories have analyzed and reported the Pb isotopic composition of NIST NBS 981. We compared all the reported data included in the GeoReM database (http://georem.mpch-mainz.gwdg.de/. A database for all kinds of reference materials and isotopic standards of geochemical and mineralogical inte

• The immunologic data demonstrate the broad cross reactivity

  2018-11-07

  

  The immunologic data demonstrate the broad cross-reactivity of vaccine-induced V3 Abs (Fig. 1 and Table 2) and recapitulate studies documenting the ability of many V3 mAbs to cross-react immunologically with diverse V3 peptides (Gorny et al., 1997), to capture virions from multiple subtypes (Nyambi

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