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br Vector construction Total RNA at a concentration
2018-11-03

Vector construction Total RNA at a concentration of 0.05µg/µL was reverse transcribed with a cDNA cycle kit (Invitrogen, Karlsruhe, Germany) using oligo dT primers and AMV reverse transcriptase. Amplification of the complete cathepsin L coding sequence was by PCR with 500ng cDNA using 0.5µM each
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br Data analysis Annotation of upstream kinase was done
2018-11-03

Data analysis Annotation of upstream kinase was done using the reported minimal consensus motifs for each kinase [1] and using KinomeXplorer (http://kinomexplorer.info) [10]. This information is annotated in Supplementary Table S1. Simple data analysis of this table can be performed using Microso
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br Data br Experimental design materials and methods br Ackn
2018-11-03

Data Experimental design, materials and methods Acknowledgements Data Silk fibroin is a natural fibrous protein with advantages for protein loading and delivery in vitro and vivo. However, presumably because of the super-negative charge of fibroin, the application of intracellular delive
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br Methods br Results br
2018-11-03

Methods Results Discussion Conclusions Conflict of interest Acknowledgements The authors gratefully acknowledge the participation of healthy young volunteers in this purchase VE-822 study. The authors of this study are funded by grants from the NIHR (LM: Academic Clinical Fellowshi
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Second individuals with ADHD compared to controls attenuated
2018-11-03

Second, individuals with ADHD, compared to controls, attenuated VLFO power to a lesser degree when working relative to resting but the spatial distribution of REST-to-WORK attenuation was similar between the two groups. The ADHD group also displayed a significantly elevated error rate during the per
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As summarized in Table our primary aim was to quantify
2018-11-03

As summarized in Table 1, our primary aim was to quantify the test–retest reliability of a range of R-fMRI metrics in school-age children with and without ADHD. Several measures of test–retest reliability are available and have been used for R-fMRI (e.g., Thomason et al., 2011; Shehzad et al., 2009;
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Examining links between sound processing in auditory midbrai
2018-11-03

Examining links between sound processing in auditory midbrain and beat synchronization could inform our knowledge of the biology responsible for transformation of perceived periodicity in auditory stimuli to motor output. Tierney and Kraus (2013a,b) have established a systematic relationship between
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A number of studies have examined the heritability of
2018-11-03

A number of studies have examined the heritability of Deforolimus imaging phenotypes, again mostly using twin designs. Global measures, such as brain volume (Baaré et al., 2001), gray matter volume (Baaré et al., 2001), and both surface area and thickness of the cortex (Panizzon et al., 2009; Eyler
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Recent research has highlighted the role of
2018-11-03

Recent research has highlighted the role of callous-unemotional (CU) traits, characterised by a lack of guilt, remorse and empathy, in increased risk for persistent antisocial behaviour and adult psychopathy (Barry et al., 2000; Frick et al., 2003; Viding, 2004; Frick and White, 2008; Frick et al.,
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br Methods br Results br Discussion In a
2018-11-03

Methods Results Discussion In a sample of typically developing community adolescents, those who had engaged in higher risk sexual behaviors differed in neural response and functional connectivity to social reward. Adolescents with higher-risk sexual behavior had greater activation than adol
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Introduction Recent theorizing and research regarding the ne
2018-11-03

Introduction Recent theorizing and research regarding the neurodevelopment of the adolescent abk has generated considerable attention in both the popular media and the scientific literature. The most striking generalization stemming from this work is that the adolescent brain does not fully mature
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Although there was no difference in
2018-11-03

Although there was no difference in the mean age of onset between acral and mucosal melanomas, KIT mutation in mucosal melanomas occurred more than a decade earlier than that in acral melanomas. Regarding the sex factor, we noticed that KIT mutation among our few cases is more commonly seen in male
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The stratum corneum of lower layers has a neutral pH
2018-11-03

The stratum corneum of lower layers has a neutral-pH microenvironment, in which LEKTI is bound to KLKs immediately after release from granular cells. Therefore, KLKs are kept in an inactivated condition. To activate KLKs, acidification of the microenvironment is required, because LEKTI is released f
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The XRD was carried out
2018-11-03

The XRD was carried out using Cr-Kα radiation X-ray tube operating with a target current of 7 mA at 30 kV (Model: Rigaku MSF 2M). The ψ angles were tilted in steps of 9° in the range of 0° to 45°. The residual stresses were estimated using the peak shift at ψ angles and d-spacing relationship of (21
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Adem s tambi n hay que
2018-11-03

Además también hay que analizar la forma en que el puritanismo que se ha filtrado en la discusión alimenta lo que Elizabeth Bernstein (2012) califica el “giro carcelario” de la política neoliberal. Bernstein encuentra que, al reformular el comercio sexual como “tráfico de mujeres”, el activismo femi
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