• Growing evidence indicates that GRKs

  2023-05-06

  

  Growing evidence indicates that GRKs can exert different effects within the cell depending on the stimulus, cell type, and localization [97], [121]. In this sense, we were the first to demonstrate a mitochondrial localization for GRK2 [122], later confirmed by other investigators [123], establishing

• Regarding the HT B receptors they act as

  2023-05-06

  

  Regarding the 5-HT1B receptors, they act as terminal receptors and are involved in the presynaptic regulation of the release of 5-HT. But at spinal level these receptors are principally situated post-synaptically (Sari, 2004). The ability of autoreceptors to regulate extracellular levels of 5-HT dur

• Small RhoGTPases are single domain nucleotide dependent bina

  2023-05-06

  

  Small RhoGTPases are single-domain nucleotide-dependent binary switches that act as highly-tuned regulators in signal transduction [1]. The cycling between active GTP-bound and inactive GDP-bound forms allows RhoGTPases to bind to or to dissociate from downstream effectors, respectively [2]. Guanine

• br GMF Remodels Actin Networks at the Leading Edge How

  2023-05-06

  

  GMF Remodels Actin Networks at the Leading Edge How are the conserved activities of GMF used in vivo to regulate branched EZLink Sulfo-NHS-Biotin Kit networks (e.g., at sites of endocytosis and at the leading edge) (Figure 2A,B)? In animal cells, the regulatory effects of GMF on actin networks a

• br Conflicts of interest br Acknowledgments br Significance

  2023-05-06

  

  Conflicts of interest Acknowledgments Significance Introduction Androgen receptor (AR) plays a paramount role in the onset and progression of prostate cancer (PC) (Burnstein, 2005, Lonergan and Tindall, 2011, Watson et al., 2015). This very facet underlies androgen deprivation therapy (A

• Inhibitors of mPGES are considered

  2023-05-06

  

  Inhibitors of mPGES-1 are considered as safe alternative to NSAIDs in the treatment of chronic inflammatory diseases that are characterized by excessive PGE2 production (Bahia et al., 2014; Khurana and Jachak, 2016; Koeberle et al., 2016; Korotkova and Jakobsson, 2014; Norberg et al., 2013; Psarra e

• HCC aetiology is multifactorial and the disease is often

  2023-05-06

  

  HCC aetiology is multifactorial and the disease is often preceded by other conditions including liver fibrosis and cirrhosis that are associated with HCV, HBV, alcoholic and non-alcoholic hepatitis. The discovery of new therapeutic targets will require a greater understanding of the pathogenic mecha

• br Exocytosis of GLUT by autophagy br Conclusion

  2023-05-06

  

  Exocytosis of GLUT4 by autophagy Conclusion Conflict of interest Ethics statement Antigen processing and presentation Adaptive immune response has to be instructed to identify and eliminate specific pathogens or foreign entities defined by their antigenic determinants. Processed antig

• Lin28 1632 br Experimental section br Acknowledgements

  2023-05-06

  

  Experimental section Acknowledgements Introduction DJ-1 is a highly conserved, homodimeric protein that was originally cloned as an oncogene capable of transforming Lin28 1632 in cooperation with activated ras[1]. DJ-1 is over-expressed in multiple tumor types and is positively correlated w

• The first and the best

  2023-05-03

  

  The first and the best-characterized mechanism of receptor-dependent internalization of Aβ is mediated via the α7-nicotinic N-Acetylneuraminic acid receptor [82]. Lipoprotein receptor protein represents the second best-studied route that facilitates the uptake of Aβ by neurons, involving additional

• Circular dichroism CD provides useful information about prot

  2023-05-02

  

  Circular dichroism (CD) provides useful information about protein structure, the extent and rate of structural changes and ligand binding. CD is a form of light Rivaroxaban spectroscopy that measures differences in the absorbance of right- and left-circularly polarized light (rather than the common

• Inflammatory factors released by activated cells during

  2023-05-02

  

  Inflammatory factors released by activated cells during AD are very important for the disease progression. Not only several inflammatory cytokines, such as IL-1β, IL-18, and IL-33, but also anti-inflammatory ones, as IL-10 and IL-13, are upregulated in the brain of AD patients (Morimoto et al., 2011

• br Discussion With recently improved understanding

  2023-04-26

  

  Discussion With recently improved understanding of the role of βARK1 in the progression of HF and as a potential therapeutic target in HF, we explored the relationship between plasma βARK1, as a marker of chronic sympathetic overactivation, and physical symptoms in HF. Our main findings were 1) e

• br Materials and methods br Results br Discussion

  2023-04-26

  

  Materials and methods Results Discussion In this study, we observed that PACAP2 immunoreactivity is mainly distributed in the telencephalon, hippocampus, and cerebellum of the zebrafish brain. This distribution pattern is similar to that reported in a previous study in which PACAP immunorea

• Regarding androgens it is known that

  2023-04-26

  

  Regarding androgens, it is known that they are also essential for reproductive success (Walters et al., 2010). At the molecular level, their effects are produced mainly by dihydrotestosterone (DHT), arising from the conversion of testosterone by the enzyme 3-oxo-5-alpha-steroid-4-dehydrogenase (enco

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