• In addition to vasoconstrictor actions

  2019-09-25

  

  In addition to vasoconstrictor actions (acute effects), ET-1 exerts potent mitogenic actions on vascular smooth muscle cells and cardiac myocytes (chronic effects), hence causing vascular and cardiac hypertrophy [19,24,25]. These effects are mediated via stimulation of either ETA or ETB receptors,

• There are two general approaches

  2019-09-25

  

  There are two general approaches to building Bayesian networks for the purpose of risk assessment. Researchers can implement static models that predict risk or survival at a snap-shot of time. For example, Loghmanpour et al. [10] created Bayesian network-based risk assessment models for patient data

• As noted earlier while exogenously administered BChE can pro

  2019-09-25

  

  As noted earlier, while exogenously administered BChE can protect against OP toxicity, its efficacy is limited by clearance of the protein from the circulation within a few days. A number of investigations have attempted to increase the circulation time of ChEs by chemical modification, gene transfe

• br Conclusions br Introduction The terms

  2019-09-25

  

  Conclusions Introduction The terms endocrine active and endocrine disruptive have been used to describe an ever-expanding list of naturally-occurring and synthetic compounds that interact with mammalian hormonal systems, and in particular, the reproductive system. These compounds have been ass

• Inappropriate heme metabolism has been linked to several neu

  2019-09-25

  

  Inappropriate heme metabolism has been linked to several neuropsychiatric disorders. In the hippocampi of Alzheimer\'s disease (AD) patients, for example, heme was found to binds intracellular amyloid β (Aβ), resulting in reduced heme bioavailability and its functional deficiency (Atamna and Frey, 2

• A structural explanation for how RBR RING s handle their

  2019-09-25

  

  A structural explanation for how RBR RING1s handle their bound E2~Ubs differently from canonical RINGs has not been readily apparent. Only a few residue positions are strongly conserved in RING and RING1 domains, most of which are zinc-coordinating Cys and histidine residues. A key position in canon

• Introduction Cholesterol plays a pivotal role as a constitue

  2019-09-25

  

  Introduction Cholesterol plays a pivotal role as a constituent of biological membranes and as a precursor for vitamins, hormones and bile acids. Accordingly, its production, distribution, and elimination must be tightly regulated at the cellular and organismal level. Accordingly, dysregulated chole

• The field of synthetic cytokine biology continues to grow th

  2019-09-25

  

  The field of synthetic cytokine biology continues to grow through molecular, physiological and pathophysiological insights, as well as via new methodical advances. The approval of chimeric antigen receptor (CAR) T cell immunotherapy by the US Food and Drug administration (FDA) in August 2017 for rel

• Prenylation may turn a flavonoid from an

  2019-09-24

  

  Prenylation may turn a flavonoid from an agonist to an antagonist and improve the selectivity to both ERs depending on the position of the substitution. C-8 prenylation appears to promote antagonism to a larger extent than C-6 in ERα due to steric hindrance against generation of agonistic conformati

• To analyze EBI expression and its function

  2019-09-24

  

  To analyze EBI2 expression and its function in T cells in vivo, we created an EGFP reporter/knockout mouse strain, termed EBI2EGFP. This mouse strain in heterozygous configuration allows for a systematic analysis of the expression of EBI2 in distinct cell types in steady-state and under inflammatory

• hnRNP E functions in a number of mRNA

  2019-09-24

  

  hnRNP E1 functions in a number of mRNA regulatory processes including transcription [74], [75], splicing [7], [74], [76], [77] and translation [6], [8], [69], [78], interacting with RNAs through CU rich regions such as the differentiation control element (DICE) and the TGFβ activated translation (BA

• br Discussion Although DNA has a limited chemical stability

  2019-09-24

  

  Discussion Although DNA has a limited chemical stability it has long been known that DNA in blood stains may remain relative stable for weeks, months, or even years at ambient temperature,1, 2, 3, 4, 5, 6 and samples (e.g., reference samples) that have been transferred to a matrix, e.g., FTA® pap

• Thus DGK active sites remain ill defined and combined

  2019-09-24

  

  Thus, DGK-active sites remain ill-defined and, combined with the lack of crystal structures for mammalian DGKs, have limited our understanding of substrate and inhibitor binding. As a result, current DGK inhibitors consist of compounds with poor specificity within the DGK superfamily (de Chaffoy de

• br Conclusion Determining whether the multiple putative alga

  2019-09-24

  

  Conclusion Determining whether the multiple putative algal DGAT isoforms are functional DGATs via biochemical assays will be vital in our effort to genetically engineer algae to produce TAG on a large enough scale to make biodiesel production viable. As can be seen in O. tauri, it is possible tha

• Aspergillus nigerA niger is another

  2019-09-24

  

  Aspergillus nigerA. niger is another filamentous fungus, in which alternative dehydrogenases have been described. Filamentous fungi are a very important group of microorganisms that are used in industry (O’Donnell et al. 2011). Biotechnological production processes using these organisms are often hi

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