• A good example of lipoxygenase assisted oxidation is

  2018-11-12

  

  A good example of lipoxygenase-assisted oxidation is the formation of six carbon aldehydes and alcohols from α-linolenic myc pathway and linoleic acid (Fig. 7) [22–24]. In the primary step, lipids are oxygenated by lipoxygenase (LOX) to form lipid hydroperoxides, which are then cleaved by hydropero

• br Conclusions and future directions The toxic effects

  2018-11-12

  

  Conclusions and future directions The toxic effects of Aβ1–42 on hippocampal neurons in culture were reversed by d-β-hydroxybutyrate, suggesting that ketone bodies may have neuroprotective efficacy [53]. Some animal studies have shown that high-fat diets are associated with elevated Aβ loads [78,

• br Experimental Procedures br Acknowledgments We are gratefu

  2018-11-12

  

  Experimental Procedures Acknowledgments We are grateful to Rosalind Gunby and Monica Autiero for careful reading and critical comments of the manuscript. We thank the Animal House and the Integrated Microscopy Facilities of IGB-Consiglio Nazionale delle Ricerche (CNR) and the Bioinformatic Cor

• In conclusion the present study utilized an in vivo

  2018-11-12

  

  In conclusion, the present study utilized an in vivo piglet model of hypoxic-preconditioning-induced ischemic tolerance to demonstrate that PC induces proliferation and neurogenesis of endogenous NSPs up to 7days after the hypoxic–ischemic insult. PC appears as a broad, non-invasive and reproducible

• In addition to identifying novel macrophage mediated regener

  2018-11-12

  

  In addition to identifying novel macrophage-mediated regenerative signalling pathways, increasing macrophage numbers in the injured heart may yield salutary results. As cTMs are anti-inflammatory and modulation of inflammation by MSCs or other mechanisms improve cardiac repair, cTM transplantation o

• br Materials and methods br Resource

  2018-11-12

  

  Materials and methods Resource table Resource details This line was derived from a 62-year-old female with familial hypertrophic cardiomyopathy (HCM). HCM is a genetic heart disease with a prevalence of up to 1 in 200 people and is characterised by unexplained hypertrophy of the left ventricl

• DNA fragmentation is an essential component of PCD

  2018-11-12

  

  DNA fragmentation is an essential component of PCD. Of several nucleases that were tested for their involvement in charontosis, EndoG emerged as a likely candidate, although a role for CAD cannot be discounted due to the degradation of ICAD observed 44 h after ETO treatment. EndoG is activated in Em

• br Materials and methods br

  2018-11-12

  

  Materials and methods Results and discussion By analyzing surface markers of glucocorticoid receptor isolated from PD effluents, we identified a Lin−/CD34+/CD38−/CD90+ (~0.14±0.03%) subpopulation (Fig. 1A), which are known to enrich for human HSCs. PD cells also contain phenotypic hematopoiet

• br Resource table Resource details We reprogrammed

  2018-11-12

  

  Resource table Resource details We reprogrammed fibroblasts obtained from a patient with Familial Mediterranean Fever (FMF), an autosomal recessively inherited autoinflammatory disease caused by mutations in the MEFV gene (The International FMF Consortium, 1997; French FMF Consortium, 1997). Pat

• Our coculture experiments demonstrated that all three MSCs s

  2018-11-12

  

  Our coculture experiments demonstrated that all three MSCs showed a similar low in vitro proliferation; for most patients coculture of all three MSCs with primary human AML endothelin receptor antagonist did not alter MSC proliferation but a minor increase in the proliferation was seen for a minori

• br Author disclosure statement br Acknowledgements Authors w

  2018-11-09

  

  Author disclosure statement Acknowledgements Authors would like to thank Dr. T. Ramakrishna Murti for his valuable comments and linguistic corrections in the manuscript. Authors would also like to thank D.I Biotech (Seoul, Korea) for support to analyze neurite outgrowth. This work was supporte

• Introduction The adult intestinal epithelium is a

  2018-11-09

  

  Introduction The adult intestinal epithelium is a self-renewing tissue with a high turnover rate maintained by intestinal stem cells that reside at the atm kinase inhibitor of glands (called crypts). Lgr5 (leucine-rich-repeat-containing G protein-coupled receptor 5), a Wnt/β-catenin target gene, e

• urokinase The C terminal sequence is crucial for maintaining

  2018-11-09

  

  The C-terminal sequence 209–223 is crucial for maintaining the structure of the active site, with its deletions leading to loss of the ligand-binding properties [49]. The carboxyl terminus of the first transmembrane domain TM1 is also involved in the formation of the binding site through close inte

• br What is the causal relation between affect biased

  2018-11-09

  

  What is the causal relation between affect-biased attention and socioemotional functioning? Statements such as “attentional bias towards threat is implicated in the development, and maintenance of anxiety” are not uncommon in the literature. Indeed, we have made the same statement in the current

• γ-Secretase inhibitor IX manufacturer Atypically high intero

  2018-11-09

  

  Atypically high interoception has been argued to characterise both panic disorder and anxiety syndromes (Ehlers, 1993; Clark, 1999; Paulus, and Stein, 2006). Indeed, individuals with heightened rates of anxiety (and panic disorder) report greater awareness of bodily sensations (see Domschke et al.,

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