The first line of treatment for the majority of primary

2018-10-20

The first-line of treatment for the majority of primary malignant bch tumors is maximal safe resection followed by radiation therapy, with or without chemotherapy, based on numerous studies that demonstrate a survival benefit with the addition of radiation (Stupp et al., 2009; Stupp et al., 2005; R

Despite these achievements in iNSC technology little is know

2018-10-20

Despite these achievements in iNSC technology, little is known on how cellular identities of iNSCs differ from those of NSCs in comparison to pluripotent stem cell-derived NPCs. For instance, it is currently unknown to what extent neural, metabolic and stress response pathways differ between these n

br Materials and methods br Acknowledgements We would like t

2018-10-20

Materials and methods Acknowledgements We would like to thank Dr. Mahito Nakanishi, Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology, for providing SeVdp. We would also like to thank the following financial supports; JSPS KAKENHI Grant

br Resource Table Resource details Endothelial to

2018-10-20

Resource Table: Resource details Endothelial-to-hematopoietic transition (EHT) is a unique developmental process that gives rise to blood cells, including hematopoietic stem p38 inhibitors (HSCs). Modeling EHT in a culture in vitro is essential for identifying the molecular program involved in H

No effective therapies are available

2018-10-20

No effective therapies are available for motor neuron diseases, including SMARD1. Neural stem cell (NSC) transplantation represents a possible therapeutic strategy for ameliorating the neurological phenotype by multiple mechanisms, including neuroprotection and cell replacement of different CNS pram

br Experimental Procedures br Author Contributions br Acknow

2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction The vital processes of blood coagulation, clot formation, and hemostasis rely upon a sufficient supply of platelets within a person’s bloodstream. Transfusion remains the most effective way to increase a patient’s

Surprisingly we discovered that among

2018-10-20

Surprisingly, we discovered that among adipose depots, Prx1-Cre activity is specific for iWAT APCs, particularly in male mice. These results were unexpected, given a prior study that reported widespread recombination in both WAT and BAT, purportedly due to recombination at the progenitor stage (Calo

PARKIN PARK an E ubiquitin ligase is the

2018-10-20

PARKIN (PARK2), an E3 ubiquitin ligase, is the most frequently mutated gene that has casually been linked to autosomal recessive early onset familial Parkinson’s disease (PD) (Abbas et al., 1999; Kitada et al., 1998). Abnormalities of PARK2 have also been described in sporadic PD (Dawson, 2006). The

br Conclusions The following are the supplementary data rela

2018-10-20

Conclusions The following are the supplementary data related to this article. Conflict of interest Acknowledgements This work was supported by The Danish Cancer Society (R.C. Grant number DP07024); Kgl. Hofbundtmester Aage Bang Fund (Grant number 55-07/08); Karen Elise Jensen Fund; Karen K

In clinical studies transplantation of neural stem

2018-10-20

In clinical studies, transplantation of neural stem src inhibitor has been applied for human cases of severe SCI; however, the therapeutic effects of NSPC transplantation are still controversial (Harrop et al., 2012). Seledtsova and colleagues transplanted human-derived NSPCs into the injured spina

In this work we developed

2018-10-20

In this work, we developed multiple tools to interrogate this autocrine and paracrine signaling loop involving α-5 laminin production by hPSCs. The use of the inducible short hairpin lines allowed us to control the dynamics of α-5 laminin production in a reversible manner. However, the interpretatio

Taken together our findings suggest that

2018-10-20

Taken together, our findings suggest that in PD, the heterozygous GBA-N370S mutation leads to the misprocessing of GCase, ER stress upregulation, and autophagic/lysosomal dysfunction in dopaminergic neurons. We propose that this combination of disturbances impairs protein homeostasis in dopamine neu

Some of the cultured cardiac

2018-10-20

Some of the cultured cardiac MSCs also stained positive for the mesodermal progenitor marker TBX18 (Mommersteeg et al., 2010; Christoffels et al., 2006); future studies need to be performed in order to address whether some of the PDGFR-α+ and TBX18+ mth1 inhibitor potentially share a developmental

Hello world!

2018-07-29