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br Conclusion br Conflict of interest
2019-05-29

Conclusion Conflict of interest Introduction Giant cell tumor (GCT) is a primary intramedullary bone tumor that is composed of mononuclear and giant mononuclear cells, resembling lactone [1]. It usually involves the end of a long bone. The World Health Organization has classified GCT as an
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br Management of warfarin during pacemaker implantable cardi
2019-05-29

Management of warfarin during pacemaker/implantable cardioverter defibrillator insertion Until recently, warfarin use was halted before PM/ICD insertion and the patient was bridged with intravenous (IV) unfractionated heparin or subcutaneous low-molecular-weight heparin (LMWH) if the thromboembol
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In this section we will
2019-05-28

In this section we will try and address many of the frequently asked questions around preventive and prophylactic measures for patients either starting or already established on bone-targeted therapy (Figs. 2 and 3). In view of the difficulties in treating ONJ, preventive strategies would seem to ma
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leukotriene b4 In addition to inducing IKs dysfunction throu
2019-05-28

In addition to inducing IKs dysfunction through dominant-negative loss-of-function effects and defective channel trafficking, mutations in KCNQ1 suppress IKs channel function by reducing the channel affinity of interacting proteins [68,69]. Phosphatidylinositol-4,5-bisphosphate (PIP2) is a cofactor
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br Case report A year old woman
2019-05-28

Case report A 41-year-old woman who had been fitted with a pacemaker for bradycardia 18 years prior presented for lead extraction on account of device infection. She had a left pectoral dual chamber pacemaker, with two tined leads: an atrial lead of 5524 M (Medtronic, Dublin, Ireland) and a ventr
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The methods used for this purpose
2019-05-28

The methods used for this purpose are, substantially, the analyses of atrial potentials, evoked atrial potentials [10], and ventricular rhythm in cases of stable spontaneous AV conduction [11]. Materials and methods Results Discussion This is the first report on the current ACAP Confirm® r
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Performance based financing often highlighted in
2019-05-28

Performance-based financing, often highlighted in Rwanda\'s story, has had mixed results when applied elsewhere, partly because of breakdowns in execution. For example, the failure of the performance-based financing initiative in neighbouring Uganda was caused by challenges in setting targets, deliv
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br India is rapidly becoming urbanised By
2019-05-28

India is rapidly becoming urbanised. By 2030, around 40% of the country\'s population will live in urban areas. The extent to which India\'s health system can provide for this large and growing city-based population will determine the country\'s success in achieving universal health coverage and i
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El eje dram tico de En la prisi
2019-05-28

El eje dramático de En la prisión… se va desarrollando trp channels través de los relatos que el Profesor, un militante de la vanguardia política revolucionaria cubana, sueña que, a su vez sueña, que narra a un grupo de “negros” durante un agobiante verano habanero de los años noventa. Todo sucede d
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Finally the effects of In NLS CSL on hematopoietic
2019-05-28

Finally, the effects of 111In-NLS-CSL360 on hematopoietic function in healthy Balb/c mice was studied. Groups of 2–4 mice were injected i.v. with 6.1±1.4MBq, 18.8±1.5MBq or 35.8±0.9MBq of 111In-NLS-CSL360 or an equivalent mass (70μg) of unlabeled CSL360 or received normal saline. At two weeks post-t
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Idelalisib demonstrates a dual mechanism
2019-05-28

Idelalisib demonstrates a dual mechanism of action by inhibiting pro-survival signalling pathways [6], and, like other kinase inhibitors, leads to re-localisation of tumour bcl-xl inhibitor by blocking ingress into and promoting egress out of the lymph node into the blood. Release from the protecti
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On Aug WHO quietly released a report that should be
2019-05-28

On Aug 23, WHO quietly released a report that should be essential reading for all. Coming 15 years after the Abuja Declaration by African governments to commit to spending 15% of annual domestic budgets on health, concludes with a stark analysis: “For every US$100 that goes into state coffers in Afr
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The communities on both sides of the South Sudan Uganda
2019-05-28

The communities on both sides of the South Sudan–Uganda border share the risk of sleeping sickness, as transmission of still occurs in this glycine transporter region. Most of the South Sudanese refugees come from endemic areas and have been accommodated in multiple camps in Adjumani and Yumbe distr
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The clinical presentation of patients with CIED pocket
2019-05-28

The clinical presentation of patients with CIED pocket infection and those with endovascular infection can vary, but once the diagnosis is made, the management is similar and involves removal of all hardware along with antibiotic therapy [2,7,8,15]. Conservative managements with AMG-517 therapy onl
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Ki16425 br Case report A years
2019-05-28

Case report A 51-years-old man visited our hospital presenting with a palpable mass over the right inguinal area which had persisted for 3 months. This lesion was approximately 3–4 cm, firm and had progressively enlarged. Laboratory data showed no remarkable anomaly except elevated lactate dehydr
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