• Introduction Multipotent stromal cells also referred to

  2018-10-24

  

  Introduction Multipotent stromal cells, also referred to as mesenchymal stem membrane transport (MSCs), are an heterogeneous subset of stromal cells present in several tissues including bone marrow, bone, adipose tissue, skin, kidney, umbilical cord and placenta (Friedenstein et al., 1968). The mi

• Main Text We appreciate the interest that Andersen et al

  2018-10-24

  

  Main Text We appreciate the interest that Andersen et al. (2014) have shown in our work on neonatal cardiac regeneration. Their recent paper relates directly to resection methodology first presented by Porrello et al. (2011) and describes a failure to reproduce the observations made in that study r

• br Results br Discussion br Experimental Procedures br Ackno

  2018-10-24

  

  Results Discussion Experimental Procedures Acknowledgments Introduction Results Discussion Experimental Procedures Author Contributions Acknowledgments Introduction Hematopoietic in vitro differentiation of pluripotent stem pregnane x receptor (PSCs) such as embryon

• Introduction Adipose stromal progenitor cells ASCs are the m

  2018-10-24

  

  Introduction Adipose stromal/progenitor Tacrolimus (ASCs) are the major reservoir of adipocyte precursors and are crucial for adipose tissue renewal, homeostasis and expansion (Berry et al., 2016; Rodeheffer et al., 2008; Tang et al., 2008; Yamamoto et al., 2007). In white adipose tissues (WAT), th

• br Results br Discussion We

  2018-10-24

  

  Results Discussion We examined gene expression in human intestinal tissue across the developmental continuum in order to determine maturity of in-vitro-derived HIOs. Using global RNA expression data obtained by RNA-seq, several different analyses demonstrated that the HIO transcriptome closely

• Finally an important practical implication of our data

  2018-10-24

  

  Finally, an important practical implication of our data is that both fibroblasts and blood can be used for the generation of comparable iPSC lines for large-scale biobanking purposes (Figure 6). Our results demonstrate that variability among small cohorts of iPSCs may lead to erroneous conclusions (

• Impaired neural migration and defects

  2018-10-24

  

  Impaired neural migration and defects in the luteolin cytoskeleton are well-known factors contributing to malformations during the cortical development (Pang et al., 2008). Reduced expression of NSUN2 in human NES cells impaired migration toward the chemoattractant FGF2. FGF2 is widely used to maint

• br Results br Discussion Genomic instability is

  2018-10-24

  

  Results Discussion Genomic instability is one of the biggest concerns in the potential clinical use of iPSCs (Rocha et al., 2013). The challenging field of regenerative medicine requires an in-depth understanding of the causes and consequences of genetic abnormalities that arise during the rep

• Although previous studies have demonstrated the ability of r

  2018-10-24

  

  Although previous studies have demonstrated the ability of research-grade HuCNS-SC lines to differentiate in both immune-suppressed and immune-deficient models (Cummings et al., 2005; Sontag et al., 2014; Ager et al., 2015), we observed no terminal differentiation in the current study. In our prior

• In this study we propose that astrocytic calcium waves are

  2018-10-24

  

  In this study, we propose that astrocytic calcium waves are long-range signals capable of transmitting the occurrence of a angiotensin ii injury to the SVZ, where they stimulate NSC proliferation and self-renewal and increase the migratory potential of NSPCs, as observed in various stroke models. A

• A complementary study confirms our findings that GATA is nec

  2018-10-24

  

  A complementary study confirms our findings that GATA6 is necessary for A-1210477 specification as well as the decreased efficiency of β-like cell generation from the GATA6 PSC line (Shi et al., 2017). This other report did have one major discrepancy with our results; they did not see a defect in g

• br Results br Discussion Comparative analyses

  2018-10-24

  

  Results Discussion Comparative analyses of non-neoplastic and neoplastic human neural populations, isolated ex vivo from fresh pathology samples, are technically challenging but can yield important insight into both normal biology and gliomagenesis. Here we provide a useful ligand-based method

• Global gene expression of RB

  2018-10-24

  

  Global gene expression of RB1-null teratomas revealed an upregulation of neural-related genes and a depleted expression of epidermal tissue-related genes. As both the nervous system and the epidermis originate from the ectoderm, these results suggest that the RB1 ablation could alter early ectoderma

• gtpase It is important to note that the

  2018-10-24

  

  It is important to note that the 2009 financial crisis brought about one of the highest unemployment rates in Western Europe (Arpaia & Curci, 2010). According to the most recent estimates, the unemployment rate in France is still above 10%, which is more than double that of the rate in the United Ki

• br Methods br Results br Discussion

  2018-10-24

  

  Methods Results Discussion Our study suggests that fructose 1 6 bisphosphatase lower educational attainment is associated with increased odds of multimorbidity in a U.S. population-based sample of adults ages 30–64. Specifically, individuals with less than a high school degree as well as t

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