• Unspecific amplification of gene expression exploits informa

  2018-10-22

  

  Unspecific amplification of gene expression exploits information intrinsic to cells, initiating a self-organizing circuitry, where gene expression cascades propagate and interact, much like the propagation of microscopic fluctuations within a critical iron magnet. Unlike an iron magnet, the circuitr

• In this study we have employed mouse NSCs rather

  2018-10-22

  

  In this study, we have employed mouse NSCs rather than human NSCs to explore the effects of PA. In view of this, further study would be desirable to ascertain if comparable effects of PA occur in human NSCs. In addition, elevated FFA level is intimately associated with oxidative stress and high leve

• Current hypotheses for this source draw on

  2018-10-22

  

  Current hypotheses for this source draw on diverse observations. Paneth boldenone undecylenate are a favored epithelial source because they reside in intimate contact with Lgr5+ ISCs (Barker et al., 2007; Cheng and Leblond, 1974) and their coculture with the latter improves intestinal organoid form

• To further verify the corneal progenitor state of cells matu

  2018-10-22

  

  To further verify the corneal progenitor state of filipin maturated in CnT-30 medium after induction with SM, we confirmed the protein expression of ABCG2, CK15, and DG-3. These proteins have been previously established as putative progenitor markers of the corneal epithelium (Chen et al., 2004; Da

• Although initial examinations of BACE null mice in the origi

  2018-10-22

  

  Although initial examinations of BACE1-null mice in the original studies suggested no overt defects in mouse growth or fertility, subsequent morphological examinations of brains and biochemical analyses of natural substrates of BACE1 began to reveal abnormal astrogenesis, reduced neurogenesis, hyper

• br Introduction Genome wide exome sequencing of microcephaly

  2018-10-22

  

  Introduction Genome-wide exome sequencing of microcephaly (MCPH) patients identified wd40-repeat protein 62 (wdr62) as the second most commonly mutated gene (Bilguvar et al., 2010; Nicholas et al., 2010; Yu et al., 2010). WDR62 is a ubiquitously expressed cytoplasmic protein in interphase and loc

• A number of important differences in gene expression

  2018-10-22

  

  A number of important differences in gene expression occurred with prolonged BMSC passage. Stem cell related genes, including Wnt and Notch signaling genes, were down-regulated in late passage cells. In addition, genes involved with DNA replication, recombination and repair, cell cycle, chromatin mo

• In the current study we investigated the

  2018-10-20

  

  In the current study, we investigated the effects of Ptp4a3 loss on the tumor-initiating cell population of colon tumors from wildtype (WT) or Ptp4a3-knockout (KO) mice using an in vitro culture system previously used to study human metastatic colon cancer stem Go 6976 (Odoux et al., 2008). The expa

• These conclusions rest mainly on three experimental facts

  2018-10-20

  

  These conclusions rest mainly on three experimental facts: a model of myocardial injury with patent coronary circulation to test the spontaneous regenerative capacity of eCSCs; in situ labelling and genetic tracking the fate of c-kit positive cardiac stem angiotensin 2 receptor blocker and the repla

• Stem cells have captivated the imagination hopes

  2018-10-20

  

  “Stem buy Sunitinib have captivated the imagination, hopes and dreams of the world.” It is seven years since I wrote this sentence to open the editorial for the inaugural issue of and the statement is even more true today than it was then. Over this period we have witnessed amazing progress in the f

• The first line of treatment for the majority of primary

  2018-10-20

  

  The first-line of treatment for the majority of primary malignant bch tumors is maximal safe resection followed by radiation therapy, with or without chemotherapy, based on numerous studies that demonstrate a survival benefit with the addition of radiation (Stupp et al., 2009; Stupp et al., 2005; R

• Despite these achievements in iNSC technology little is know

  2018-10-20

  

  Despite these achievements in iNSC technology, little is known on how cellular identities of iNSCs differ from those of NSCs in comparison to pluripotent stem cell-derived NPCs. For instance, it is currently unknown to what extent neural, metabolic and stress response pathways differ between these n

• br Materials and methods br Acknowledgements We would like t

  2018-10-20

  

  Materials and methods Acknowledgements We would like to thank Dr. Mahito Nakanishi, Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology, for providing SeVdp. We would also like to thank the following financial supports; JSPS KAKENHI Grant

• br Resource Table Resource details Endothelial to

  2018-10-20

  

  Resource Table: Resource details Endothelial-to-hematopoietic transition (EHT) is a unique developmental process that gives rise to blood cells, including hematopoietic stem p38 inhibitors (HSCs). Modeling EHT in a culture in vitro is essential for identifying the molecular program involved in H

• No effective therapies are available

  2018-10-20

  

  No effective therapies are available for motor neuron diseases, including SMARD1. Neural stem cell (NSC) transplantation represents a possible therapeutic strategy for ameliorating the neurological phenotype by multiple mechanisms, including neuroprotection and cell replacement of different CNS pram

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