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Compared to treatments with other FGF isoforms stimulation w
2018-11-08
Compared to treatments with other FGF2 isoforms, stimulation with 22.5kDa FGF2 results in lower stem cell gene expression in hESCs (Fig. 4d), weaker proliferative activity in human dermal fibroblasts (Fig. 5), and lower relative mitogenic activity in BaF3 order AEBSF ectopically expressing FGFR1 II
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Previously in vitro studies of CIPN were performed in
2018-11-08
Previously, in vitro studies of CIPN were performed in rat pheochromocytoma or SK-N-SH human neuroblastoma cell lines as model systems to evaluate decreases in neurite outgrowth in response to neurotoxic chemotherapy drugs, such as paclitaxel, vincristine, oxaliplatin and cisplatin (Rovini et al., 2
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Introduction Human pluripotent stem cells hPSCs i e human em
2018-11-08
Introduction Human pluripotent stem γ-Secretase inhibitor IX (hPSCs), i.e., human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), can give rise to functional neurons (reviewed in Gage and Temple, 2013). Human peripheral neurons are difficult to differentiate, but a
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Many laboratories have analyzed and reported the Pb isotopic
2018-11-07
Many laboratories have analyzed and reported the Pb isotopic composition of NIST NBS 981. We compared all the reported data included in the GeoReM database (http://georem.mpch-mainz.gwdg.de/. A database for all kinds of reference materials and isotopic standards of geochemical and mineralogical inte
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The immunologic data demonstrate the broad cross reactivity
2018-11-07
The immunologic data demonstrate the broad cross-reactivity of vaccine-induced V3 Abs (Fig. 1 and Table 2) and recapitulate studies documenting the ability of many V3 mAbs to cross-react immunologically with diverse V3 peptides (Gorny et al., 1997), to capture virions from multiple subtypes (Nyambi
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De acuerdo con el Ing
2018-11-07
De acuerdo con el Ing. Marcos Lechuga (ex empleado de Concarril), quien recuerda estos años y el modelo de los 180 carros fabricados por Bombardier en Canadá entre 1982-1985, Cabe destacar que paralelo a este aumentó de las importaciones de coches del metro Concarril avanzaba vertiginosamente en la
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Myopia has been linked to
2018-11-07
Myopia has been linked to urbanization; however, in this study, no differences were noted between T1D, uveitis, and SLE patients and control subjects in terms of urbanization (Tables 1 and 2). The results indicate that the inflammatory reactions initiated by T1D, uveitis, and SLE are major contribut
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Among the participants in our study
2018-11-07
Among the 1303 participants in our study, 74% (n=964) reported xerostomia (Table 2). Xerostomia prevalence was highest among SS participants (87.4%, 95% CI: 84.8%–89.8%) followed by Sicca participants (72.4%, 95% CI: 67.4%–77.0%) and the ISS group (38.1%, 95% CI: 32.0%–44.4%). The absolute differenc
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aminoguanidine br Methods br Results br Discussion Mechanica
2018-11-07
Methods Results Discussion Mechanical stretch via tissue expanders stimulates proliferation and maturation in both embryonic and adult aminoguanidine (Mihic et al., 2014; Banerjee et al., 2015). In adult skin, mechanical tension induces fibroblasts proliferation and collagen synthesis (Won
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Though protective against the target diseases DTP may increa
2018-11-07
Though protective against the target diseases, DTP may increase susceptibility to unrelated infections (Aaby et al., 2003b, 2004a, 2012) (Appendix A). The SAGE review noticed that the majority of studies found a detrimental effect of DTP (Higgins et al., 2014). However, SAGE considered the evidence
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br Introduction Polycystic ovary syndrome PCOS is
2018-11-07
Introduction Polycystic ovary syndrome (PCOS) is a common and multifactorial disease that affects approximately 4%–18% of all reproductive-aged women in the world (Moran et al., 2011). In the clinic, hyperandrogenism and insulin resistance appear to be the major etiological drivers for reproducti
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The vaccine development approach pursued by the GSK Vaccines
2018-11-07
The vaccine development approach pursued by the GSK Vaccines Institute for Global Health (GVGH) is based on Generalized Modules for Membrane Antigens (GMMA). GMMA are approximately 50nm outer membrane blebs derived from bacteria genetically modified to enhance shedding and to reduce reactogenicity o
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Teresa May parece no tener una pol tica propia ni
2018-11-07
Teresa May parece no tener una política propia ni un liderazgo fuerte para llevar dgat1 inhibitor buen término la negociación con la ue ocasionada por el Brexit, además los hechos de terrorismo y los accidentes la han mostrado como débil y no del todo competente frente a una Europa que ha endurecid
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br MS data interpretation by database DB
2018-11-07
MS data interpretation by database (DB) searching ProteinLynx Global Server (PLGS) v2.5 (Waters) was used for peak picking and DB searching as described previously [3]. The searching DB contains 20,273 human protein entries extracted from UniProtKB/Swiss-Prot Release 2014_01. The DB searching res
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Dried fractions were reconstituted in acetonitrile
2018-11-07
Dried fractions were reconstituted in 10% acetonitrile (100μl) and injected (20μl) onto an Aeris PEPTIDE XB-C18 100×2.1mm column, with solid core 1.7μm particles (100Å) (Phenomenex, Torrance, CA). RP-LC was performed (300μl/min, 40°C) on a Nexera UHPLC system (Shimadzu, Columbia, MD) with water (A)
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