• In recent years there has been growing interest regarding

  2019-04-20

  

  In recent years, there has been growing interest regarding the role of spliceosome machinery in neoplastic diseases following evidence of the involvement of splicing factor mutations in diverse cancers . (Serine-Arginine Splicing Factor 2) is a member of the serine/arginine (S/A) rich family pre-mR

• SAR 405 br Introduction Acute myeloid leukemia AML remains

  2019-04-19

  

  Introduction Acute myeloid leukemia (AML) remains a hematologic malignancy with poor outcome and a high risk for relapse believed to be caused by the survival of leukemic stem cells (LSCs), which are responsible for disease repopulation following treatment [1]. This important implication of LSCs

• br Substantial gains have been made

  2019-04-19

  

  Substantial gains have been made globally for many of the health targets, but progress in the improvement of health has been unequal with respect to the most vulnerable populations, and major discrepancies persist across regions and socioeconomic status. Maternal immunisation is a unique opportu

• The Mexico City Policy is also flawed on evidentiary and

  2019-04-19

  

  The Mexico City Policy is also flawed on evidentiary and public health grounds. A 2011 study found that enforcement of the Mexico City Policy by the George W Bush administration led to an increase in abortion rates in sub-Saharan Africa, probably because of decreased contraception access and increas

• Three possible mechanisms may underlie the decrease in the n

  2019-04-19

  

  Three possible mechanisms may underlie the decrease in the number of PVBs in the present patient: the first is the antiarrhythmic action of Omacor, the second is the natural time course of PVBs, and the third is the day-to-day variability in the number of PVBs. Therefore, we performed an additional

• br The L type calcium channel LTCC in heart consists

  2019-04-19

  

  The L-type calcium channel (LTCC) in heart consists of 4 subunits: α1, β2, α2, and δ [47], encoded by CACNA1C, CACNB2, and CACNA2D, respectively, with the α2 and δ subunits encoded by the gene CANA2D. In 2007, Antzelevitch et al. [48] reported 2 CACNA1C mutations and a CACNB2 mutation from a genot

• br Discussion Pocket hematoma is a frequent

  2019-04-19

  

  Discussion Pocket hematoma is a frequent complication in the early stages following cardiac device IWR-1-endo manufacturer and its incidence has been reported to be 0.9–22% [11–16,18–22]. In this study, 161 patients underwent cardiac device surgery and 10 (6.2%) of these patients had bleeding co

• Hereditary syndromes with increased risk for gastric

  2019-04-19

  

  Hereditary syndromes with increased risk for gastric cancer include: 1) hereditary diffuse gastric cancer, 2) Lynch syndrome/hereditary non-polyposis colorectal cancer, 3) juvenile polyposis syndrome, 4) Peutz-Jeghers syndrome and 5) familial adenomatous polyposis. Hereditary diffuse gastric cancer

• The canonical or catenin dependent Wnt signaling pathway

  2019-04-19

  

  The canonical, or β-catenin dependent, Wnt signaling pathway is critical for the regulation of osteoblast proliferation and survival [95]. Soluble inhibitors of the canonical Wnt pathway such as Dickkopf (DKK1), produced by OBL, and sclerostin, from osteocytes, play important roles in the regulation

• Apart from their association with severe pain

  2019-04-19

  

  Apart from their association with severe pain and reduced quality of life, SREs require substantial healthcare resource utilization (HRU) in their treatment and management. Previous retrospective studies have attempted to quantify various aspects of the burden of SREs across specific tumor types/cou

• A recent meta analysis has shown that an enlarged LA

  2019-04-19

  

  A recent meta-analysis has shown that an enlarged LA increases the risk of AF recurrence after a single CPVI, regardless of the follow-up duration [5]. This finding can be applied to paroxysmal and persistent AF [6,7]. In clinical practice, measurement of LAD can provide a window into the status of

• br Discussion T wave oversensing is caused by

  2019-04-19

  

  Discussion T-wave oversensing is caused by alternations or variations in intracardiac electrograms for reasons such as hyperglycemia, drugs, sympathetic tones, ventricular pacing, and hyperkalemia. Several similar cases of hyperkalemia-induced T-wave oversensing with inappropriate ICD therapies h

• br Conclusion br Funding br Conflict of interest br

  2019-04-19

  

  Conclusion Funding Conflict of interest Acknowledgments Introduction Ventricular tachyarrhythmias (VTs) are life-threatening events that result in hemodynamic compromise; therefore, patients often require immediate treatment such as electrical cardioversion. Despite appropriate manage

• br Conclusion br Limitations br

  2019-04-19

  

  Conclusion Limitations Conflict of interest Introduction The prevalence of sirtuin activators and inhibitors failure prevalence is increasing throughout the world. The reasons for this pandemic include the aging populations of both industrialized and developing nations and a growing inc

• De acuerdo con los planteamientos anteriores pensemos en

  2019-04-19

  

  De acuerdo con los planteamientos anteriores pensemos en la propuesta que se obtendría desde la obra de Villoro respecto gamma-Secretase inhibitor IX la situación política para un miembro perteneciente a una comunidad indígena, en tanto que además de pertenecer a ella se reconozca como ciudadano del

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