• br Acknowledgements br Introduction Major research interests

  2018-10-22

  

  Acknowledgements Introduction Major research interests have been attributed to reactive oxygen species (ROS) and their likely involvement in human physiopathology from the health point over the last few decades. Oxidative stress, caused by an imbalance between antioxidant systems and the produ

• In the present study there is apparently no

  2018-10-22

  

  In the present study, there is apparently no compensatory mechanism in visceral organs in order to overcome STZ induced oxidative stress. Reduced activities of SOD and CAT in liver, kidney and heart have been observed during diabetes. SOD is vital defence enzyme which catalyses the dismutation of su

• br Materials and methods br

  2018-10-22

  

  Materials and methods Results and discussions Conclusion The capability of the CTs extracts to scavenge free radicals in different systems, indicating that they may be useful therapeutic agents for treating various chronic diseases which are more related to oxidative stress associated disea

• Beside its efficacy in the treatment of refractory epilepsy

  2018-10-22

  

  Beside its efficacy in the treatment of refractory epilepsy, the ketogenic diet has been suggested to be useful in the therapy of neurodegenerative and neuromuscular diseases including AD, Parkinson’s disease, amyotrophic lateral sclerosis and mitochondrial disorders [34]. The ketogenic diet is like

• ddPCR is claimed to possess advantages

  2018-10-22

  

  ddPCR is claimed to possess advantages over qPCR, including absolute quantification, unparalleled precision, increased signal-to-noise ratio, removal of PCR bias, reduced consumable costs, lower equipment costs and superior partitioning. However, ddPCR does have a limitation in quantifying high numb

• br Conclusions A simplified schematic model is

  2018-10-22

  

  Conclusions A simplified schematic model is proposed (see Fig. 7) illustrating how Lox and Twist are involved in the BMP4-induced EMT-like response and adipocyte lineage commitment. In brief, BMP4 results in increased expression of Lox (Huang et al., 2009) and Twist thus promotes the EMT-like res

• Unspecific amplification of gene expression exploits informa

  2018-10-22

  

  Unspecific amplification of gene expression exploits information intrinsic to cells, initiating a self-organizing circuitry, where gene expression cascades propagate and interact, much like the propagation of microscopic fluctuations within a critical iron magnet. Unlike an iron magnet, the circuitr

• In this study we have employed mouse NSCs rather

  2018-10-22

  

  In this study, we have employed mouse NSCs rather than human NSCs to explore the effects of PA. In view of this, further study would be desirable to ascertain if comparable effects of PA occur in human NSCs. In addition, elevated FFA level is intimately associated with oxidative stress and high leve

• Current hypotheses for this source draw on

  2018-10-22

  

  Current hypotheses for this source draw on diverse observations. Paneth boldenone undecylenate are a favored epithelial source because they reside in intimate contact with Lgr5+ ISCs (Barker et al., 2007; Cheng and Leblond, 1974) and their coculture with the latter improves intestinal organoid form

• To further verify the corneal progenitor state of cells matu

  2018-10-22

  

  To further verify the corneal progenitor state of filipin maturated in CnT-30 medium after induction with SM, we confirmed the protein expression of ABCG2, CK15, and DG-3. These proteins have been previously established as putative progenitor markers of the corneal epithelium (Chen et al., 2004; Da

• Although initial examinations of BACE null mice in the origi

  2018-10-22

  

  Although initial examinations of BACE1-null mice in the original studies suggested no overt defects in mouse growth or fertility, subsequent morphological examinations of brains and biochemical analyses of natural substrates of BACE1 began to reveal abnormal astrogenesis, reduced neurogenesis, hyper

• br Introduction Genome wide exome sequencing of microcephaly

  2018-10-22

  

  Introduction Genome-wide exome sequencing of microcephaly (MCPH) patients identified wd40-repeat protein 62 (wdr62) as the second most commonly mutated gene (Bilguvar et al., 2010; Nicholas et al., 2010; Yu et al., 2010). WDR62 is a ubiquitously expressed cytoplasmic protein in interphase and loc

• A number of important differences in gene expression

  2018-10-22

  

  A number of important differences in gene expression occurred with prolonged BMSC passage. Stem cell related genes, including Wnt and Notch signaling genes, were down-regulated in late passage cells. In addition, genes involved with DNA replication, recombination and repair, cell cycle, chromatin mo

• In the current study we investigated the

  2018-10-20

  

  In the current study, we investigated the effects of Ptp4a3 loss on the tumor-initiating cell population of colon tumors from wildtype (WT) or Ptp4a3-knockout (KO) mice using an in vitro culture system previously used to study human metastatic colon cancer stem Go 6976 (Odoux et al., 2008). The expa

• These conclusions rest mainly on three experimental facts

  2018-10-20

  

  These conclusions rest mainly on three experimental facts: a model of myocardial injury with patent coronary circulation to test the spontaneous regenerative capacity of eCSCs; in situ labelling and genetic tracking the fate of c-kit positive cardiac stem angiotensin 2 receptor blocker and the repla

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