No effective therapies are available

2018-10-20

No effective therapies are available for motor neuron diseases, including SMARD1. Neural stem cell (NSC) transplantation represents a possible therapeutic strategy for ameliorating the neurological phenotype by multiple mechanisms, including neuroprotection and cell replacement of different CNS pram

br Experimental Procedures br Author Contributions br Acknow

2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction The vital processes of blood coagulation, clot formation, and hemostasis rely upon a sufficient supply of platelets within a person’s bloodstream. Transfusion remains the most effective way to increase a patient’s

Surprisingly we discovered that among

2018-10-20

Surprisingly, we discovered that among adipose depots, Prx1-Cre activity is specific for iWAT APCs, particularly in male mice. These results were unexpected, given a prior study that reported widespread recombination in both WAT and BAT, purportedly due to recombination at the progenitor stage (Calo

PARKIN PARK an E ubiquitin ligase is the

2018-10-20

PARKIN (PARK2), an E3 ubiquitin ligase, is the most frequently mutated gene that has casually been linked to autosomal recessive early onset familial Parkinson’s disease (PD) (Abbas et al., 1999; Kitada et al., 1998). Abnormalities of PARK2 have also been described in sporadic PD (Dawson, 2006). The

br Conclusions The following are the supplementary data rela

2018-10-20

Conclusions The following are the supplementary data related to this article. Conflict of interest Acknowledgements This work was supported by The Danish Cancer Society (R.C. Grant number DP07024); Kgl. Hofbundtmester Aage Bang Fund (Grant number 55-07/08); Karen Elise Jensen Fund; Karen K

In clinical studies transplantation of neural stem

2018-10-20

In clinical studies, transplantation of neural stem src inhibitor has been applied for human cases of severe SCI; however, the therapeutic effects of NSPC transplantation are still controversial (Harrop et al., 2012). Seledtsova and colleagues transplanted human-derived NSPCs into the injured spina

In this work we developed

2018-10-20

In this work, we developed multiple tools to interrogate this autocrine and paracrine signaling loop involving α-5 laminin production by hPSCs. The use of the inducible short hairpin lines allowed us to control the dynamics of α-5 laminin production in a reversible manner. However, the interpretatio

Taken together our findings suggest that

2018-10-20

Taken together, our findings suggest that in PD, the heterozygous GBA-N370S mutation leads to the misprocessing of GCase, ER stress upregulation, and autophagic/lysosomal dysfunction in dopaminergic neurons. We propose that this combination of disturbances impairs protein homeostasis in dopamine neu

Some of the cultured cardiac

2018-10-20

Some of the cultured cardiac MSCs also stained positive for the mesodermal progenitor marker TBX18 (Mommersteeg et al., 2010; Christoffels et al., 2006); future studies need to be performed in order to address whether some of the PDGFR-α+ and TBX18+ mth1 inhibitor potentially share a developmental

Hello world!

2018-07-29