• POE specialises Rogers definition of

  2021-01-22

  

  POE specialises Rogers' definition of engineering [37] to systems engineering as: As such, systems engineering becomes a problem solving exercise, the problem being, given a physical environment E, to find the system S that JNJ-38877605 receptor meets a real-world need N to the satisfaction of a g

• Functional studies revealed that these ESR mutations lead to

  2021-01-22

  

  Functional studies revealed that these ESR1 mutations lead to constitutive activity of the ER, meaning that the receptor is active in absence of estrogen, conferring resistance against several endocrine agents. Recent studies reported that the occurrence of ESR1 mutations is rare in ER+ primary brea

• WP 1130 In a study performed simultaneously by another group

  2021-01-22

  

  In a study performed simultaneously by another group, EWS-FLI-1 introduction into unsorted murine bone marrow-derived WP 1130 resulted in tumors with various phenotypes including one that is consistent with that of Ewing sarcoma [68]. The tumors expressed markers associated with Ewing sarcoma and d

• EphB and ephrinB mRNA levels

  2021-01-22

  

  EphB4 and ephrinB2 mRNA levels were determined from three parts taken from each tumor, and each sample was analyzed in triplicate. The differences in the histoscores and mRNA levels of EphB4 and ephrinB2 were analyzed by Student's t test. The correlation coefficients were evaluated both by linear re

• br Materials and methods br

  2021-01-22

  

  Materials and methods Results Discussion In particular, we showed that pancreatic neuroendocrine tumor Meropenem trihydrate synthesis recognize cAMP as a stimulatory signal for cell proliferation. Conversely, cAMP was found to have an inhibitory effect on cell proliferation in bronchial ca

• br Materials and methods br Results br Discussion Here we

  2021-01-22

  

  Materials and methods Results Discussion Here we show expression of the EP1 receptor in the hippocampus of mice and the functional influence of the EP1 receptor on kainic cgrp antagonist induced seizures. Mice lacking a functional EP1 receptor gene displayed a lower tendency to enter statu

• br Acknowledgement We acknowledge for funding support

  2021-01-22

  

  Acknowledgement We acknowledge for funding support from Maryada Foundation, a DoD/Army Contract No. W911NF-06-1-0095, and National Institutes of Health through the New England Center of Excellence for Biodefense (Grant AI057159-01). Introduction The Gram-negative bacterium Lysobacter sp. XL1

• br Materials and methods br Results br

  2021-01-22

  

  Materials and methods Results Discussion Anti-EGFR therapy for epithelial carcinomas has important clinical significance, but widespread intrinsic or acquired resistance seriously affects efficacy. Mutation and heterodimerization of EGFR are the two main causes of resistance to anti-EGFR th

• br Materials and methods br Results br Discussion Drug

  2021-01-22

  

  Materials and methods Results Discussion Drug of abuse induces widespread KL 001 australia changes in the molecular and cellular functions in circuits between VTA and its neighbored regions such as NAC, and amygdala. It is belived that these changes result behavioral phenotype that charact

• Nanocomposite films with a GNP

  2021-01-22

  

  Nanocomposite films with a GNP-DNA filler concentration of 20 wt%, 30 wt%, and 40 wt% were investigated by electrical impedance spectroscopy before and after UV-C irradiation (Fig. 2). EIS data were fitted to a RC-circuit model and surface resistivity values were calculated from the fitted resistanc

• Soybean Glycine max is an important

  2021-01-21

  

  Soybean (Glycine max) is an important oilseed and can be a useful source of epoxy fatty acids (EFAs). This UFA contains an oxygen bridge across adjacent carbon atoms at single or multiple positions in the acyl chain, making them highly reactive and prone to cross-linking, and thus valuable industria

• Collagen compaction and alignment are generated by

  2021-01-21

  

  Collagen compaction and alignment are generated by cell-mediated contractile forces (Stopak and Harris, 1982). The transmission of actomyosin forces to collagen has been mainly attributed to integrins and the activation of the Rho-ROCK pathway (Clark et al., 2007, Kural and Billiar, 2013, Provenzano

• Air trapping at the small airways

  2021-01-21

  

  Air-trapping at the small airways is related to severe AEBSF (Bjermer, 2014), and acute exacerbation (Mahut et al., 2010). Although asthma patients are generally treated with inhaled corticosteroid (ICS) or with ICS and long-acting β2 agonist (LABA), the efficacy of such treatment depends on drug p

• urokinase The mammalian two hybrid results described above w

  2021-01-21

  

  The mammalian two-hybrid results described above were all obtained in 293T cells, and thus the higher RLU observed specific to the hCrm1 fusion could be consistent with human urokinase having an unknown activator that interacts with hCrm1 HEAT repeat 9A and somehow facilitates Crm1-Rev/RRE function.

• Behaviors were compared between saline and amphetamine

  2021-01-21

  

  Behaviors were compared between saline and amphetamine pre-treatment groups at 24h and 2 weeks following the last treatment, or between pre-treatment groups that received vehicle or ASV-30 infusions, using separate two-way ANOVAs. Significant effects were analyzed further using Student–Newman–Keuls

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